[Sca-cooks] More of coffee and sugar spikes:

[marilyn traber 011221]

OK, here's a technical description, for those of you who speak in tongues ;-0

Phlip

Here is a snippit from the Journal of Medical Hypothesis talking 
about coffee and glucose absorption.....   And if you want it 
explained, perhaps Ibrahim will do the honors.. I'm on 
vacation!          :-)   KvE. 

"Indeed, there is recent evidence that coffee increases production 
of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly 
owing to an inhibitory effect of chlorogenic acid (CGA -- the chief 
polyphenol in coffee) on glucose absorption. GLP-1 acts on beta 
cells, via cAMP-dependent mechanisms, to promote the synthesis and 
activity of the transcription factor IDX-1, crucial for maintaining 
the responsiveness of beta cells to an increase in plasma glucose. 
Conversely, the "glucolipotoxicity" thought to initiate and sustain 
beta cell dysfunction in diabetics can suppress expression of this 
transcription factor. The increased production of GLP-1 associated 
with frequent coffee consumption could thus be expected to 
counteract the adverse impact of chronic free fatty acid 
overexposure on beta cell function in overweight insulin resistant 
subjects. CGA's putative impact on glucose absorption may reflect 
the ability of this compound to inhibit glucose-6-phosphate 
translocase 1, now known to play a role in intestinal glucose 
transport. Delayed glucose absorption may itself protect beta cells 
by limiting postprandial hyperglycemia -- though, owing to 
countervailing effects of caffeine on plasma glucose, and a paucity 
of relevant research studies, it is still unclear whether coffee 
ingestion blunts the postprandial rise in plasma glucose. More 
generally, diets high in "lente carbohydrate", or administration of 
nutraceuticals/pharmaceuticals which slow the absorption of dietary 
carbohydrate, should help preserve efficient beta cell function by 
boosting GLP-1 production, as well as by blunting the glucotoxic 
impact of postprandial hyperglycemia on beta cell function.