[Sca-cooks] More of coffee and sugar spikes:
marilyn traber 011221
phlip at 99main.com
Thu May 4 16:16:10 PDT 2006
OK, here's a technical description, for those of you who speak in tongues ;-0
Phlip
Here is a snippit from the Journal of Medical Hypothesis talking
about coffee and glucose absorption..... And if you want it
explained, perhaps Ibrahim will do the honors.. I'm on
vacation! :-) KvE.
"Indeed, there is recent evidence that coffee increases production
of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly
owing to an inhibitory effect of chlorogenic acid (CGA -- the chief
polyphenol in coffee) on glucose absorption. GLP-1 acts on beta
cells, via cAMP-dependent mechanisms, to promote the synthesis and
activity of the transcription factor IDX-1, crucial for maintaining
the responsiveness of beta cells to an increase in plasma glucose.
Conversely, the "glucolipotoxicity" thought to initiate and sustain
beta cell dysfunction in diabetics can suppress expression of this
transcription factor. The increased production of GLP-1 associated
with frequent coffee consumption could thus be expected to
counteract the adverse impact of chronic free fatty acid
overexposure on beta cell function in overweight insulin resistant
subjects. CGA's putative impact on glucose absorption may reflect
the ability of this compound to inhibit glucose-6-phosphate
translocase 1, now known to play a role in intestinal glucose
transport. Delayed glucose absorption may itself protect beta cells
by limiting postprandial hyperglycemia -- though, owing to
countervailing effects of caffeine on plasma glucose, and a paucity
of relevant research studies, it is still unclear whether coffee
ingestion blunts the postprandial rise in plasma glucose. More
generally, diets high in "lente carbohydrate", or administration of
nutraceuticals/pharmaceuticals which slow the absorption of dietary
carbohydrate, should help preserve efficient beta cell function by
boosting GLP-1 production, as well as by blunting the glucotoxic
impact of postprandial hyperglycemia on beta cell function.
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